Volume 1 ; 1 ; in Month : Jan-Dec (2025) Article No : 101
Effo KE, Kouakou MAAJ, Dah O, et al.

Abstract

Diabetes remains a public health problem due to the limitations of conventional treatments. Traditional medicine offers an alternative. “Pancréas Free” is a remedy produced by an Ivorian traditional practitioner to treat diabetes. This study aimed to evaluate the safety and antihyperglycemic activity of “Pancréas Free.” The safety of Pancréas Free was evaluated according to OECD 423 and OECD 407 guidelines. The hypoglycemic risk of Pancréas Free at doses of 4.5, 9, and 18 mg/kg was investigated. The anti-hyperglycemic activity of the same doses was evaluated in an induced-hyperglycemia animal model. Blood glucose levels of rats were checked before hyperglycemia was induced and then every hour for 4 hours. ‘Pancréas Free’ did not cause any signs of clinical toxicity or lethality up to 2000 mg/kg. When administered once daily for 28 days, “Pancréas Free” also showed no signs of clinical, hematological, or biochemical toxicity. “Pancréas Free” did not cause a significant decrease in fasting blood glucose levels. “Pancréas Free” caused a non-significant reduction in induced hyperglycemia. This decrease was more pronounced from the third hour for doses of 4.5 mg/kg and 18 mg/kg, and from the second hour at the dose of 9 mg/kg. Pancréas Free demonstrates good clinical, hematological, renal, and hepatic tolerance as well as low antihyperglycemic activity without hypoglycemic risk. Its combined use, according to the traditional practitioner's protocol, could justify its use in the treatment of diabetes.

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