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<title>Bioscience-Biotechnology-Pharmacology-Communications-ISSUE VOLUME Volume 1 ISSUE 1</title>
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Bioscience-Biotechnology-Pharmacology-Communications: VOLUME Volume 1 ISSUE 1, Jan-Dec 2025
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<title>Bioscience-Biotechnology-Pharmacology-Communications-ISSUE VOLUME Volume 1 ISSUE 1</title>
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		<title>Safety-and-antihyperglycemic-activity-of-Pancra-free-an-antidiabetic-remedy-formulated-by-an-Ivorian-traditional-practitioner</title>
		<pubDate>13-Aug-2025</pubDate>
<link>http://bbbc.edwiserinternational.com/admin/uploads/FqsHST.pdf</link>
		<author>Effo-KE-Kouakou-MAAJ-Dah-O-et-al-</author>
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		<category>Pharmaceutical Science,Medical Science,Clinical Science</category>
		<description>{<![CDATA[Diabetes remains a public health problem due to the limitations of conventional treatments. Traditional medicine offers an alternative. Pancras Free is a remedy produced by an Ivorian traditional practitioner to treat diabetes. This study aimed to evaluate the safety and antihyperglycemic activity of Pancras Free.The safety of Pancras Free was evaluated according to OECD 423 and OECD 407 guidelines. The hypoglycemic risk of Pancras Free at doses of 4.5, 9, and 18 mg/kg was investigated. The anti-hyperglycemic activity of the same doses was evaluated in an induced-hyperglycemia animal model. Blood glucose levels of rats were checked before hyperglycemia was induced and then every hour for 4 hours.Pancras Free did not cause any signs of clinical toxicity or lethality up to 2000 mg/kg. When administered once daily for 28 days, Pancras Free also showed no signs of clinical, hematological, or biochemical toxicity. Pancras Free did not cause a significant decrease in fasting blood glucose levels. Pancras Free caused a non-significant reduction in induced hyperglycemia. This decrease was more pronounced from the third hour for doses of 4.5 mg/kg and 18 mg/kg, and from the second hour at the dose of 9 mg/kg. Pancras Free demonstrates good clinical, hematological, renal, and hepatic tolerance as well as low antihyperglycemic activity without hypoglycemic risk.  Its combined use, according to the traditional practitioner's protocol, could justify its use in the treatment of diabetes. ]]>}</description>
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